標(biāo)題: 奶牛肥胖綜合癥 [打印本頁(yè)] 作者: monica 時(shí)間: 2007-8-17 23:33 標(biāo)題: 奶牛肥胖綜合癥 奶牛肥胖綜合癥Fat Cow Syndrome (Fatty Liver Syndrome)
Prepared by: Dr. Terry Hunt
病因/發(fā)病機(jī)理 Cause & Pathogenesis
• 體脂代謝過度，肝內(nèi)貯藏
Mobilization of excessive quantities of fat from body stores that is then deposited in the liver
• 泌乳早期對(duì)能量需求突然增加
Caused by sudden demand for energy in early lactation dairy cows
• 低發(fā)病率高死亡率
Low morbidity but high mortality
危險(xiǎn)因素 Risk Factors
• 最大化泌乳量時(shí)的管理操作
Management practices aimed at maximizing milk yield/cow
• 產(chǎn)犢時(shí)體況評(píng)分4分以上
Cows with a body condition score of over 4 at calving
• 其它圍產(chǎn)期疾病導(dǎo)致飼料攝入量下降
Other peri-parturient diseases resulting in a sudden decrease in feed intake
臨床癥狀 Clinical Findings
• 僅在產(chǎn)犢后出現(xiàn)
Occurs just after calving
• 既往史并發(fā)病如胎衣滯留/產(chǎn)褥熱
Usually a history of concurrent disease such as retained placenta or Milk fever
• 食欲廢絕
Complete anorexia
• 體重下降快
Rapid weight loss
• 奶產(chǎn)量突然下降
Sudden decrease in milk production
• 臥地、漸進(jìn)性消瘦
Weakness progressing to recumbency
• 重癥酮病
Severe ketosis
• 有時(shí)目光呆滯
Staring gaze and opisthotonus in some
• 心動(dòng)過速和昏迷
Terminal tachycardia and coma
• 7-10天內(nèi)死亡 Death in 7-10 days
實(shí)驗(yàn)結(jié)果 Laboratory Findings
• 低血糖、酮尿、酮血癥
Hypoglycemia, ketonemia and ketonuria
• 膽紅素和肝酶水平上升
Elevated serum bilirubin and liver enzymes
尸解 Post Mortem
• 肝腫大、蒼白、易碎
Liver grossly enlarged, pale and friable
• 有多種并發(fā)癥
There may be concurrent disease
診斷 Diagnosis
• 依據(jù)臨床癥狀和排除其它疾病
Based on clinical signs and rule-out of other diseases
• 實(shí)驗(yàn)室結(jié)果對(duì)診斷有幫助
• Laboratory results are helpful
治療 Treatment
• 監(jiān)護(hù)預(yù)后情況
Prognosis is guarded at best
• 每天靜注50%右旋葡萄糖500mL
Intravenous glucose – 500 ml of 50% dextrose daily
• 全身靜脈補(bǔ)液+口服電解質(zhì)
Intensive intravenous fluids plus balanced electrolytes orally
• 皮質(zhì)類固醇，每隔兩天注射20mg地塞米松
Corticosteroids – 20 mg of Dexamethasone every 2nd day
• 口服丙二醇
225ml Oral propylene glycol – 225 ml bid
• 瘤胃液接種
Rumen fluid transplants
預(yù)防 Prevention & Control
• 干奶期避免過肥
Avoid over-fat cows during the dry period
• 使用體況評(píng)分管理牛群
Utilize BCS to sort cows into management groups
• 干奶期使用優(yōu)質(zhì)草料
Use good quality forage during dry period